Products

5-FOA (5-Fluoroorotic acid)

Product Overview

  • Molecular Weight:192.1
  • Molecular Formula:C5H3FN2O4.H2O
  • CAS:220141-70-8
  • Storage:-20 to 4°C
  • Size:50 mg
  • Purity: ≥98%
  • Melting Range: ~285° C
  • Technical Data Sheet:5-FOA-MSDS.pdf

Product Description



5-FOA (5-Fluoroorotic acid), Monohydrate

Used as a research tool in molecular genetics. Employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5-phosphate decarboxylase deficient. 5-FOA is converted 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potential inhibitor of thyidylate Sythase (TS), causing a cessation in DNA synthesis.

Specification:

Synonyms: 5-FOA; FOA, 2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic Acid; 5-Fluorouracil-4-carboxylic Acid

Solubility: 50mg in 1ml (1:1) ammonium hydroxide-water with gentle heating.

Harmful by inhalation, in contact with skin and if swallowed.

References:

Kondo, S. et al., (1991) J. Bacteriology, 173 (23), 7698-7700.

Vidal, M. et al., (1996) Proc. Natl. Acad. Sci. USA, 93, 10321.

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